A Comparative study of Magnesium Sulphate and Clonidine nebulizations in attenuation of pressor response to direct laryngoscopy, intubation and post operative sore throat.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To evaluate and compare the effect of Magnesium sulphate and Clonidine nebulizations on the haemodynamic response upon laryngoscopy and tracheal intubation.
研究概览
简要总结
As the procedures of laryngoscopy and tracheal intubation during induction of general anesthesia cause increase in heart rate and blood pressure, the search for an ideal agent to attenuate the pressor response has been ongoing. Any drug given intravenously for the same has other systemic deleterious effects. Hence, the nebulisation route,a safer and alternative route, will be evaluated is this study using two drugs exclusively which are known to attenuate the response. The two agents being Magnesium Sulphate and Clonidine. Also, their effect on the post operative sore throat will be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients who are willing to give written/ informed consent.
- •Patients undergoing elective surgeries under general anaesthesia.
- •Patients belonging to ASA I and II.
- •Patients aged between 18-60 years of age of both genders.
排除标准
- •Patients not willing to give written/informed consent.
- •Patients prone to allergies.
- •Patients with prior history of sore throat.
- •Patients with neurological pathologies 5) Patients with cardiovascular instabilities.
结局指标
主要结局
To evaluate and compare the effect of Magnesium sulphate and Clonidine nebulizations on the haemodynamic response upon laryngoscopy and tracheal intubation.
时间窗: 4- 5 hours
次要结局
- To evaluate and compare the effect of Magnesium sulphate and clonidine nebulizations on postoperative sore throat.(24 -36 hours after intubation)