A Comparative study of Magnesium Sulphate and Clonidine nebulizations in attenuation of pressor response to direct laryngoscopy, intubation and post operative sore throat.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- To evaluate and compare the effect of Magnesium sulphate and Clonidine nebulizations on the haemodynamic response upon laryngoscopy and tracheal intubation.
Study Overview
Brief Summary
As the procedures of laryngoscopy and tracheal intubation during induction of general anesthesia cause increase in heart rate and blood pressure, the search for an ideal agent to attenuate the pressor response has been ongoing. Any drug given intravenously for the same has other systemic deleterious effects. Hence, the nebulisation route,a safer and alternative route, will be evaluated is this study using two drugs exclusively which are known to attenuate the response. The two agents being Magnesium Sulphate and Clonidine. Also, their effect on the post operative sore throat will be evaluated.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients who are willing to give written/ informed consent.
- •Patients undergoing elective surgeries under general anaesthesia.
- •Patients belonging to ASA I and II.
- •Patients aged between 18-60 years of age of both genders.
Exclusion Criteria
- •Patients not willing to give written/informed consent.
- •Patients prone to allergies.
- •Patients with prior history of sore throat.
- •Patients with neurological pathologies 5) Patients with cardiovascular instabilities.
Outcomes
Primary Outcomes
To evaluate and compare the effect of Magnesium sulphate and Clonidine nebulizations on the haemodynamic response upon laryngoscopy and tracheal intubation.
Time Frame: 4- 5 hours
Secondary Outcomes
- To evaluate and compare the effect of Magnesium sulphate and clonidine nebulizations on postoperative sore throat.(24 -36 hours after intubation)