To find out which of the drugs; Magnesium sulphate or Clonidine given through nasal route, provide optimal conditions during administration of general anesthesia.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/08/035814
• Lead Sponsor: Dr Smitha K S

Brief Summary

As the procedures of laryngoscopy and tracheal intubation during induction of general anesthesia cause increase in heart rate and blood pressure, the search for an ideal agent to attenuate the pressor response has been ongoing. Any drug given  intravenously for the same has other systemic deleterious effects. Hence, the nebulisation route,a safer and alternative route, will be evaluated is this study using two drugs exclusively which are known to attenuate the response. The two agents being Magnesium Sulphate and Clonidine. Also, their effect on the post operative sore throat will be evaluated.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-08-18
• Study Start: 2021-08-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 1. Patients who are willing to give written/ informed consent.
• 2)Patients undergoing elective surgeries under general anaesthesia.
• 3)Patients belonging to ASA I and II.
• 4)Patients aged between 18-60 years of age of both genders.

Exclusion Criteria

• 1)Patients not willing to give written/informed consent.
• 2)Patients prone to allergies.
• 3)Patients with prior history of sore throat.
• 4. Patients with neurological pathologies 5) Patients with cardiovascular instabilities.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate and compare the effect of Magnesium sulphate and Clonidine nebulizations on the haemodynamic response upon laryngoscopy and tracheal intubation.	4- 5 hours

Secondary Outcome Measures

Name	Time	Method
To evaluate and compare the effect of Magnesium sulphate and clonidine nebulizations on postoperative sore throat.	24 -36 hours after intubation

Trial Locations

Locations (1)

Bangalore Medical College and Research Institute; 🇮🇳 Bangalore, KARNATAKA, India

Bangalore Medical College and Research Institute

🇮🇳Bangalore, KARNATAKA, India

Dr Smitha K S

Principal investigator

9886935506

smi9685@gmail.com