Correlation of Serum Uric Acid / Hdl-Cholesterol Ratio And Inflammatory Markers in Patients with High Troponin-T Levels – An Observational Case Control Study

Hyperuricemia is associated with metabolic syndrome, Diabetes mellitus (DM) and its complications. Low HDL-C is associated with high risk for atherosclerosis and myocardial infarction. Increased Uric acid/HDL-C ratio (UHR) is associated with, metabolic syndrome, DM and its complications, and Non-alcoholic fatty liver disease. UHR has been shown as an new biomarker for evaluating interactions between inflammatory and anti-inflammatory substances in blood.

In the year 2020, the prevalence of MI in Indians was 21.4% for diabetics and 11% for non-diabetics. Metabolic inflammation or Chronic low grade systemic inflammation (also called as adipose inflammation) is one of the risk factor for pathogenesis of Myocardial Infarction (MI). MI is a complication of metabolic disorders like DM and Metabolic syndrome. And Troponin T is a commonly used cardiac marker for diagnosis of MI. Troponin T concentration is significantly associated with the incidence of cardiovascular death and heart failure, and also a predictor of acute MI. Hence this study was under taken to assess the correlation between Uric acid/HDL-C ratio and inflammatory markers with myocardial infarction indicator, ie Troponin T.