Ablation of Sympathetic Atrial Fibrillatio
Not Applicable
Completed
- Conditions
- <p>Atrial fibrillation, hypertension</p>10007521
- Registration Number
- NL-OMON24798
- Lead Sponsor
- Isala klinieken, department of Cardiology, Zwolle
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 145
Inclusion Criteria
The patient falls within the target group resistent hypertension or symphatic overdrive
Patient is an acceptable candidate for renal denervation treatment
Exclusion Criteria
Contraindication to chronic anticoagulation therapy or heparin
Previous left heart ablation procedure for AF
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Time to first detection of atrial fibrillation (AF) >30 seconds, with the monitoring period starting 3 months after the intervention.</p><br>
- Secondary Outcome Measures
Name Time Method <p>AF burden after 12 months of follow-up, expressed in % of the monitoring period, in patients with continuous rhythm monitoring. The monitoring period starts 3 months after the intervention. Blood pressure at 3, 6, 12 months after the intervention, and change in blood pressure compared to measurement before the intervention<br /><br>Blood pressure and heart rate response changes induced by exercise testing<br /><br>Changes in heart rate variability measures tested by Holter monitoring compared to measurement before the intervention<br /><br>Changes in arterial stiffness measures post intervention AASI (ambulatory arterial stiffness index) by ambulatory blood pressure monitoring, PWV (pulse wave velovity) and augmentation index compared to measurement before the intervention</p><br>