A clinical study to evaluate the level of bacterial toxins in failed root canal treated teeth after doing root canal irrigation and applying a medicament
Phase 4
- Conditions
- Health Condition 1: K049- Other and unspecified diseases ofpulp and periapical tissues
- Registration Number
- CTRI/2022/03/041237
- Lead Sponsor
- SRM Dental College Ramapuram
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA score 1.
Healthy patients aged between 16-60 years.
Previously root canal treated teeth done minimum 2 years or more having symptomatic apical periodontitis. (PAI <=2).
Single rooted teeth with single canal having closed apex.
Exclusion Criteria
Teeth with PAI >2.
ASA score 2-5.
Patients who have undergone root canal treatment <2 years ago.
Periodontally compromised teeth.
Multirooted and single rooted teeth with more than one canal.
Teeth with poor prognosis and endodontic mishaps.
Teeth having weeping canals.
Teeth treated with posts.
Patients under any medications for a week (before the procedure).
Teeth with immature apex.
All the excluded patients will receive the appropriate treatments but not be included in the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantification and comparison of endotoxins before and after continuous chelation will show a decrease in endotoxin concentration levels.Timepoint: Samples will be taken at three time intervals - Immediately after GP removal (baseline) and after chemomechanical preparation.
- Secondary Outcome Measures
Name Time Method Comparison of endotoxins after placement of calcium hydroxide will show complete elimination. Comparison of endotoxin at three time intervals will show reduction at each time interval.Timepoint: Level of endotoxin concentration will be compared between the baseline and 7 days after placement of calcium hydroxide.