Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium

Not Applicable

Completed

• Conditions: Laryngeal Injuries
• Interventions: Drug: Sevoflurane; Drug: Rocuronium

• Registration Number: NCT01591031
• Lead Sponsor: University of Rostock

Brief Summary

Anesthesia induction with sevoflurane is not associated with an increased incidence or severity of laryngeal injuries compared with an anesthesia induction with a muscle relaxant.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04
• Study First Submitted: 2012-04-27
• Study First Submitted QC: 2012-05-02
• Study First Posted: 2012-05-03
• Status Verified: 2013-02
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Last Update Submitted: 2013-02-13
• Last Update Posted: 2013-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ear-nose-throat surgery
• orotracheal intubation for surgery of the ear

Exclusion Criteria

• obesity
• allergy against the study drugs
• patients with a known or suspected difficult airway (Mallampati score 3 or 4 and a mouth opening < 3.5 cm).
• all patients were examined by stroboscopy one day before surgery and were excluded from the study when preexisting pathologies of the vocal cords were found

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sevoflurane	Sevoflurane	anesthesia induction with propofol, remifentanil and sevoflurane
rocuronium	Rocuronium	anesthesia induction with propofol, remifentanil and rocuronium

Primary Outcome Measures

Name	Time	Method
incidence of vocal cord injuries	24 h after tracheal intubation

Secondary Outcome Measures

Name	Time	Method
incidence of hoarseness	24h, 48 h, and 72 h after tracheal intubation
incidence of soar throat	24h, 48h, and 72 h after tracheal intubation

Trial Locations

Locations (1)

University of Rostock; 🇩🇪 Rostock, Mecklenburg/Vorpommern, Germany