NCT02641665Unknown不适用
Measurement of Four Plasma Biomarkers for Risk Stratification and Determination of Functional Recovery After Cardiac Valve Surgery
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Composite primary outcome
研究概览
简要总结
The level of four biomarkers will be measured in the patients' plasma after induction of anaesthesia. There biomarkers are NT-ProBNP, ST2, Galectin-3 and GDF-15. The level of these marker will then be correlated with early (30 days) and late (one year) patients' prognosis and with functional recovery (MLHFQ score).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Elective/urgent aortic or mitral valve surgery in isolation or combined with CABG
排除标准
- •Emergency or salvage surgery
- •Inability to consent
- •Previous cardiac surgery
- •Stage IV or V CDK (GFR ≤ 30 ml/min) or dialysis
- •Active Endocarditis
- •Liver cirrhosis
- •Chronic atrial fibrillation
- •Pacemaker
结局指标
主要结局
Composite primary outcome
时间窗: 30 days
In hospital or 30-days mortality or inotropic support during more than 48 hours or lengthy of ICU stay longer than 5 days
次要结局
- one year mortality(1 year)
- ICU readmission(30 days)
- NYHA(1 year)
- Post-operative AKI(48 hours)
- Ejection fraction(1 year)
- reshopitalisation(1 year)
- MLHFQ(1 year)
研究者
Jean François Brichant
Professor, Head of Department
University of Liege
研究点 (1)
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