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Management of Hypotension In the Extremely Preterm Infant

Phase 1
Conditions
ow Blood Pressure
MedDRA version: 17.1Level: LLTClassification code 10024895Term: Low blood pressureSystem Organ Class: 100000004866
Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]
Registration Number
EUCTR2010-023988-17-CZ
Lead Sponsor
BrepCo Biopharma Limited
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
ot Recruiting
Sex
All
Target Recruitment
830
Inclusion Criteria

•Gestational age from 23 weeks at birth to less than 28 completed weeks (i.e. up to and including 27 weeks and 6 days).
•Within 72 hours of birth.
•An indwelling arterial line, suitably calibrated and zeroed, to monitor blood pressure.
•A pre-trial cranial ultrasound scan free of grade III-IV IVH or cystic PVL.
•A mean blood pressure (BP) 1 mmHg or more below a mean BP value equivalent to the GA in completed weeks, which persists over a 15 minute period.

Are the trial subjects under 18? yes
Number of subjects for this age range: 830
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

•Infant is considered non-viable by attending clinicians.
•Life-threatening congenital abnormalities including congenital heart disease and chromosomal abnormalities.
•Infants known to require surgical treatment.
•Hydrops Fetalis.

Study & Design

Study Type
Interventional clinical trial of medicinal product
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod
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