NCT00979940终止不适用
Effects of Short Term, High Dose Atorvastatin Therapy on Periprocedural Myonecrosis and Platelet Inhibition After PCI
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Periprocedural Myonecrosis
研究概览
简要总结
This research study plans to evaluate the use of atorvastatin in patients with coronary artery disease given immediately before PCI and whether it will decrease the amount of heart damage after PCI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing revascularization for significant coronary artery disease
- •age range 21-85 years
排除标准
- •non-STEMI, STEMI
- •renal failure with creatinine>3.0mg/dl
- •liver cirrhosis
- •lymphoproliferative disorder
- •pregnancy
- •thrombocytopenia<150'000
- •coagulopathy (INR>1.5)
- •abnormal liver function tests
- •illicit drug use
- •history of statin intolerance
- •history of rhabdomyolysis
- •planned use of Glycoprotein IIb/IIIa inhibitors during PCI
- •current therapy with atorvastatin, pravastatin, lovastatin, fluvastatin, or rosuvastatin
研究组 & 干预措施
atorvastatin
Experimental
Atorvastatin 80mg po given prior to PCI in cath lab
干预措施: Atorvastatin (Drug)
结局指标
主要结局
Periprocedural Myonecrosis
时间窗: 16-24 hours post PCI
次要结局
未报告次要终点
研究者
研究点 (2)
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