The clinical validation of a dried blood spot method for vancomycin and creatinine

Recruiting

• Conditions: concentration of antibiotic in blood following infection; 10004018

• Registration Number: NL-OMON54384
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Aged 18 and over
- Able to understand written information and able to give informed consent
- Treated with vancomycin
- Able and willing to undergo a finger prick for dried blood spot sampling
- Able and willing to fill in a questionnaire

Exclusion Criteria

unable to draw blood samples for study purposes

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To clinically validate the DBS method for vancomycin and creatinine in<br /><br>comparison to venipuncture vancomycin and creatinine analysis </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Analyzing the differences in the measured concentrations in the dried blood<br /><br>spot made with blood obtained from venous sampling and capillary sampling.<br /><br>- Evaluating the need of a correction factor and optimizing the correction<br /><br>factor when measuring the hematocrit in the DBS samples<br /><br>- To investigate the patients* experience with the DBS method in comparison to<br /><br>venipuncture</p><br>