The clinical validation of a dried blood spot method for immunosuppressive drugs and creatinine

Recruiting

• Conditions: Transplantatie; Concentrations of drugs in blood following transplantation

• Registration Number: NL-OMON56304
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 260

Inclusion Criteria

- Aged 18 and over
- Able to understand written information and able to give informed consent
- Treated with tacrolimus, everolimus, sirolimus and/or ciclosporin
- Able and willing to undergo a finger prick for dried blood spot sampling
- Able and willing to fill in a questionnaire

Exclusion Criteria

Unable to draw blood samples for study purposes

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Correlation between the DBS concentrations and venous blood concentrations of<br /><br>immunosuppressive drugs and creatinine.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Analyzing the differences in the measured concentrations in the dried blood<br /><br>spot made with blood obtained from venous sampling and capillary sampling.<br /><br>- Evaluating the need of a correction factor when measuring the hematocrit in<br /><br>the DBS samples<br /><br>- Analyzing the difference between the drug concentration in the microtainer<br /><br>and filtrate card, to investigate the influence of the filtrate card on the<br /><br>drug concentration</p><br>