Phase Ib study of Valproic Acid (VPA) and 13-cis-RA(isotretinoin) combination therapy for advanced and recurrent neuroblastoma.
Phase 1
- Conditions
- advanced and recurrent neuroblastoma
- Registration Number
- JPRN-UMIN000010834
- Lead Sponsor
- ational Cancer Research Center Hospital Division of Pediatric Oncology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
1.active double cancer(synchronous double cancer and metachronous double cancer within 5 disease -free years),excluding carcinoma In situ(lesions equal to Intraepithelial or intramucosal Cancer)judged to have been cured with local treatment. 2.active infection requiring systemic medication. 3.abnormality in electrocardiogram tested within 28 days,requiring intervention. 4.respiratory or heart disorder requiring oxygen supply,except from malignant pleural effusion. 5.women during pregnancy or breast-feeding. 6.Psychosis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method