A clinical trial comparing two different modes of blood purification in patients with recent onset kidney shut down due to some illness
Not Applicable
- Conditions
- Health Condition 1: null- Acute kidney injury patients requiring renal replacement therapy
- Registration Number
- CTRI/2017/09/009675
- Lead Sponsor
- PGIMER chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. AKI stage 3 of KDIGO classification or Acute on CKD patients fulfilling standard criteria for requirement of renal replacement therapy
2. Presence of SIRS, fulfilling at least 2 out of 4 criteria
Exclusion Criteria
1. Patients with hypotension requiring more than single inotropes
2. CKD and post renal transplant patients already on some form of renal replacement therapy
3. Indication of dialysis, toxin or drug removal
4. AKI patients with suspected or confirmed Glomerulonephritis, vasculitis or obstructive AKI
5. Terminal illness with associated life expectancy less than 2 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To examine the feasibility of conducting a larger study that will determine whether convective clearance confers improved outcome as compare to diffusive clearance using intermittent modes of RRT <br/ ><br> <br/ ><br>2. To compare outcome in terms of renal recovery in patients with AKI and SIRS, undergoing online hemodiafiltration vs conventional hemodialysisTimepoint: 1 month
- Secondary Outcome Measures
Name Time Method Change in body fluid levels as assessed by bioimpedance machineTimepoint: 7 days;Change in qSOFA scoreTimepoint: 7 days;Change in serum cytokine concentration (IL6)Timepoint: 7 days;Mortality benefit <br/ ><br>Timepoint: 1 month