Effect of High-volume Online hemodiafiLtration on intra-diaLytic hemodynAmic (iN)sTability and cardiac function in chronic hemodialysis patients (the HOLLANT study)
Completed
- Conditions
- cardiac function and blood pressure in dialysis paitents1001928010038430
- Registration Number
- NL-OMON50492
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
- treatment with hemodialysis or hemodiafiltration 3 x per week during at least
4 hours for at least 2 months
- ability to understand study procedures
- willingness to provide informed consent
- spKt/Vurea * 1.2
- achievement of blood flow of *360 ml/min and/or convection volume of >23
Liter per treatment during the run-in phase
- access recirculation <10%
Exclusion Criteria
- current age < 18 years
- severe incompliance to dialysis procedure and accompanying prescriptions,
especially frequency and duration of dialysis treatment
- life expectancy < 3 months
- participation in another clinical intervention trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>During dialysis treatment:<br /><br>nadir in systolic blood pressure (SBP) of 90 mmHg for patient with predialysis<br /><br>SBP <160mmHg and a nadir of 100 mmHg for patients with predialysis SBP *160<br /><br>mmHg during treatment<br /><br>(blood pressure will be measured before and every 15 minutes after the start of<br /><br>dialysis during the treatment; during 3 consecutive treatments with each<br /><br>treatment-modality).</p><br>
- Secondary Outcome Measures
Name Time Method