Multi-elemental Imaging of Lung Tissues With LIBS (Laser-induced Breakdown Spectroscopy)

Completed

• Conditions: Interstitial Lung Disease; Sarcoidosis; Idiopathic Pulmonary Fibrosis

• Registration Number: NCT03901196
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Evaluate the feasibility of performing a multi-elemental imaging analysis of lung specimens from patients with ILDs, with an technology named LIBS (Laser Induced-Breakdown Spectroscopy)

Detailed Description

There is a major health problem due to the environmental and occupational related exposures to mineral particles, metals, and dust. The impact on health is considerable in terms of prevalence, morbidity and healthcare costs. Pathologists rarely report the presence of a possible mineral or metal-related etiology in a specimen by lack of available and convenient technology. Therefore, several respiratory diseases are considered idiopathic.

Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD) is a group of lung diseases affecting the interstitium (the tissue and space around the air sacs of the lungs). In France, 15.000 new cases of ILD are diagnosed each year. ILD may be classified according to the cause. Idiopathic ILD are ILD of unknown causes. The most frequent idiopathic ILD are sarcoidosis and idiopathic pulmonary fibrosis (IPF).These two diseases are the core topic of the present study since they may relate to important mineral or metal exposure.

The overall goal of this MEDICO-LIBS study is to evaluate the feasibility of using a laser-induced breakdown spectroscopy (LIBS)-based instrument to image(ie, identify, localize and possibly quantify) metals within selected human specimens with ILDs.

Study Timeline

• Study First Submitted: 2019-03-28
• Study First Submitted QC: 2019-04-01
• Study First Posted: 2019-04-03
• Study Start: 2020-01-22
• Primary Completion: 2024-04-09
• Study Completion: 2024-04-09
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-29
• Last Update Posted: 2024-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• Patient with ILD
• Patient informed, and agreed to participate

Exclusion Criteria

• Patient opposed to participating in the study.
• Patient without available specimen.
• Patient under legal protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Generation of multi-elemental images in tissues with LIBS	Within a month after reception of the biopsy by the analytical laboratory	Evaluation of the feasibility of collecting and describing LIBS multi-elemental images of lung specimens originating from patients with ILDs

Secondary Outcome Measures

Name	Time	Method
Description of elemental distribution in the specimens	Within a month after reception of the biopsy by the analytical laboratory	Comprehensive chemical characterization of both endogenous and exogenous elements for each specimen
Interpretation of the elemental maps	Within a month after reception of the biopsy by the analytical laboratory	Understanding of the elemental distribution according to the clinical data
Comparison of the elemental distributions with results of other mineralogical investigations	Within a month after reception of the biopsy by the analytical laboratory	Only for patients who previously benefited from other mineralogical investigations (eg, SEM-EDX), comparison of mineralogical analysis obtained with the elemental distributions obtained with LIBS

Trial Locations

Locations (4)

Grenoble Alpes University Hospital; 🇫🇷 Grenoble, France

CHRU de LILLE; 🇫🇷 Lille, France

CHU de Lyon HCL - GH Sud; 🇫🇷 Lyon, France

Hôpital Louis Pradel; 🇫🇷 Lyon, France