The effect of Erythromycin on feeding intolerance in premature infants
Phase 3
- Conditions
- feeding intolerance.Underfeeding of newborn
- Registration Number
- IRCT20120614010026N10
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
premature infants
weight lower than 1800 grams
feeding volume less than 75 cc/kg/ day in the 14th day after birth
frequent lavage (i.e. => 2 times lavage; >50% of milk volume)
parents willingness
Exclusion Criteria
presence of sepsis
gastrointestinal anomalies
cyanotic heart disease
history of operation on gastrointestinal system in the first 14 days after birth
consumption of medication effective in erythromycin metabolism in the same time
incidence of arrhythmia or prolonged QT interval
parents unwillingness
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time duration to reach to 75, 110 and 150 cc/kg/ day feeding volume. Timepoint: daily, during intervention. Method of measurement: observation.
- Secondary Outcome Measures
Name Time Method Time duration of oxygen dependency. Timepoint: during intervention. Method of measurement: observation.;Time duration of hospitalization. Timepoint: during intervention. Method of measurement: observation.;Sepsis incidence. Timepoint: during intervention. Method of measurement: physical examination.;Necrotizing enterocolitis incidence. Timepoint: during intervention. Method of measurement: physical examination.