Effect of Dexmedetomidine on Outcomes During Emergence From Retroperitoneal Laparoscopic Surgery
Overview
- Phase
- Not Applicable
- Intervention
- dexmedetomidine
- Conditions
- Anesthesia
- Sponsor
- Air Force Military Medical University, China
- Enrollment
- 66
- Locations
- 1
- Primary Endpoint
- Richmond Score
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The study is to observe whether dexmedetomidine could reduce agitation during emergence from general anesthesia in patients undergoing retroperitoneal laparoscopic surgery.
Detailed Description
Agitation during emergence is frequent after retroperitoneal urologic surgery. Dexmedetomidine is alpha-2 receptor agonist which shows sedative and algesic effect. In this study we will compare the effect of dexmedetomidine given by different protocols on emergence agitation.
Investigators
Zhihong LU
Dr
Air Force Military Medical University, China
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for retroperitoneal laparoscopic surgery
- •Patients with written informed consent
Exclusion Criteria
- •Patients with difficulty of communication
- •Patients with risk of obstructive sleeping apnea syndrome
Arms & Interventions
dexmedetomidine loading dose
dexmedetomidine is given at load dose
Intervention: dexmedetomidine
dexmedetomidine loading dose
dexmedetomidine is given at load dose
Intervention: loading dose
dexmedetomidine sustaining dose
dexmedetomidine is given at sustaining dose
Intervention: dexmedetomidine
dexmedetomidine sustaining dose
dexmedetomidine is given at sustaining dose
Intervention: sustaining dose
Outcomes
Primary Outcomes
Richmond Score
Time Frame: From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour
Secondary Outcomes
- Time to awake(From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour)
- Cough score(From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour)