Impact of Exercise Therapy on Functional Capacity in Patients Listed for Liver Transplantation
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Liver Cirrhosis
- Sponsor
- Matthew Armstrong
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Number of participants with intervention-related adverse events as assessed by CTCAE v4.0
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
A UK prospective, single-centre feasibility study investigating the effects of exercise therapy on functional capacity in patients on the waiting list for liver transplantation. Patients will receive a 12-week home prehabilitation program (daily step program; functional resistance exercise sessions; telephone health call or virtual clinic). The following will be assessed at weeks 0, 6 and 12 weeks: feasibility (recruitment, compliance, safety, patients perception), functional capacity (ISWT, SPBT), psychological wellbeing (HADS questionnaire) and quality of life (EQ-5D)
Detailed Description
as above
Investigators
Matthew Armstrong
Principal investigator, Specialist Registrar in Hepatology and Honorary Clinical Fellow
University of Birmingham
Eligibility Criteria
Inclusion Criteria
- •Meet the United Kingdom Liver Transplant criteria for listing
- •Accepted on the liver transplant waiting list for a primary transplant
- •Adults ≥18years who have an indication for a liver transplant
- •Diagnosed with sarcopenia at liver transplant assessment
Exclusion Criteria
- •Significant cardiovascular instability including a recent Myocardial infarction, recent Cerebrovascular accident and/or a recent unstable arrhythmia
- •Unstable encephalopathy - open to interpretation by the chief investigator
- •Patient or next of kin non-English speaking
- •Inpatients
- •Refusal or lacks capacity to give informed consent
Outcomes
Primary Outcomes
Number of participants with intervention-related adverse events as assessed by CTCAE v4.0
Time Frame: 12-week
As this is a feasibility/Pilot study the investigators need to assess if any participants have any adverse events related to the home prehabilitation programme and if so, determine the severity and frequency