Proving Utility of a New Field-cycling MRI Prototype in Acute Stroke Patients

Not yet recruiting

• Conditions: Stroke Acute

• Registration Number: NCT07004140
• Lead Sponsor: University of Aberdeen

Brief Summary

The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can show changes in the brain within the first day of a stroke due to a blocked blood vessel or bleeding in the brain. The main question it aims to answer is:

• Can FCI identify brain tissue that might recover within the first few hours after a stroke begins?

Participants will undergo a standard MRI scan and an FCI scan, as soon as possible after hospital admission.

Participants who have had a blocked blood vessel will also provide a blood sample and will have a follow up visit at 30 days for repeat of both scans and providing another blood sample.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-05
• Study First Submitted: 2025-05-26
• Study First Submitted QC: 2025-05-26
• Last Update Submitted: 2025-05-26
• Study Start: 2025-06
• Study First Posted: 2025-06-04
• Last Update Posted: 2025-06-04
• Primary Completion: 2026-05
• Study Completion: 2026-05

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Acute stroke (<24 hours from symptom onset).
• NIHSS ≥4 and <25 with cortical involvement and/or large vessel occlusion on baseline imaging.
• Able to undergo 3T and FCI MRI <24h of onset.
• With or without thrombolysis.

Exclusion Criteria

• Contraindications to MRI.
• Medically unstable.
• Unable to comprehend or comply with instructions regarding scanning
• Prior mRS of >3.
• Identified for thrombectomy.
• Non-stroke pathology or previous cortical infarct on CT scan > 1/3 of middle cerebral artery territory.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Agreement between extent of ischaemic stroke at-risk tissue/infarct core obtained from FCI dispersion maps and 3T MRI modalities at baseline	Baseline at stroke onset	Receiver operator curves (ROC) curves comparing extent of at-risk tissue/infarct core obtained from FCI dispersion maps and from 3T MRI modalities at baseline at stroke onset.

Secondary Outcome Measures

Name	Time	Method
Agreement between extent of haemorrhagic volume obtained from FCI dispersion maps and 3T MRI modalities at baseline	Baseline at stroke onset	Receiver operator curves (ROC) curves comparing extent of haemorrhagic volume obtained from FCI dispersion maps and from 3T MRI modalities at baseline at stroke onset.
Agreement of infarct core volume measurements obtained from FCI and 3T MRI at day 30 in ischaemic stroke patients	30 days after stroke onset	Comparison of infarct core volumes on 30-day 3T FLAIR and baseline/30-day FCI T1 dispersion maps in ischaemic stroke patients.
Agreement between T1 dispersion curve measurements obtained from in vivo clot in large intracerebral vessels and clot formed in vitro.	At baseline and 30 days after stroke onset	Extent of agreement between quantified T1 dispersion curve measurements obtained from in vivo imaging and benchtop Fast Field Cycling Nuclear Magnetic Resonance (FFC-NMR). Extent of correlation between thrombo-elastography measurements against in vivo measurements of T1 dispersion.

Trial Locations

Locations (1)

University of Aberdeen; 🇬🇧 Aberdeen, United Kingdom