NCT05505396已完成不适用
Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury in the Intensive Care Unit - a Prospective, Observational Cohort Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 459
- 试验地点
- 1
- 主要终点
- Functional outcome at 6 months as evaluated by the modified Rankin Scale.
研究概览
简要总结
This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome.
Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Admission to the neurointensive care unit at Rigshospitalet
- •Diagnosis of acute brain injury categorised as TBI, SAH, ICH, ischaemic stroke, or other conditions
排除标准
- •Brain death before inclusion
- •Closest relatives do not understand written and spoken Danish or English
结局指标
主要结局
Functional outcome at 6 months as evaluated by the modified Rankin Scale.
时间窗: 6 months after admission.
Modified Rankin Scale ranges from 0-6, where 0 is the best and 6 is the worst outcome.
次要结局
- All-cause mortality at 6 months (dichotomous).(6 months after admission.)
- Length of stay in the neuro-ICU (continuous).(Day of discharge, typically 1-30 days after admission.)
研究者
Alexandra Vassilieva
Principal Investigator
Rigshospitalet, Denmark
研究点 (1)
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