Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients With Severe Acute Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- (Change in) MD-glucose (mmol/L)
研究概览
简要总结
Acute brain injury is a serious condition that often results in admission to an intensive care unit. Some of the most seriously ill patients are fitted with multimodal neuromonitoring, a newer monitoring modality that can, among other things, measure oxygen tension and sugar levels in brain tissue. It is common clinical practice, but the interaction between the body's sugar levels and the brain's sugar levels is not sufficiently elucidated.
The study will investigate the relationship between the body's sugar levels, measured in arterial and venous blood, and the brain's sugar level, measured by microdialysis, in patients with severe acute brain injury.
Furthermore, we hope to be able to use our measurements to set up a mathematical model for the brain's sugar uptake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •Admission to the neuro-ICU at Rigshospitalet.
- •Multimodal neuromonitoring
排除标准
- •Closest relative does not understand written and spoken Danish or English.
- •Patients with known diabetes mellitus upon admission.
研究组 & 干预措施
Hyperglycaemic clamp
The purpose of hyperglycaemic clamping is to raise the blood glucose level to a fixed plateau and maintain the plateau for at least one hour to observe a steady-state blood glucose concentration.
The investigators intend to perform the hyperglycaemic clamping procedure one time in all 14 patients following an overnight fast and aim for a fixed blood glucose level above 8 mmol/L.
The patient will have an arterial line placed in the radial artery, a retrograde catheterization of the jugular bulb and a venous line for infusions of glucose, potassium, and isotonic saline.
To maintain potassium levels at wanted levels, an isotonic saline solution containing potassium will be infused continuously and arterial samples of potassium and glucose will be measured at minimum every 10 minutes from the start of the intervention.
干预措施: Hyperglycaemic clamp (Other)
结局指标
主要结局
(Change in) MD-glucose (mmol/L)
时间窗: Throughout the intervention, approximately five hours
Change in) MD-glucose (mmol/L) over time as a function of (a set change in) arterial blood glucose (mmol/L)
次要结局
- Jugular vein glucose (mmol/L) over time as a function of arterial blood glucose.(Throughout the intervention, approximately five hours)
- Lactate-pyruvate-ratio (LP-ratio) as a function of arterial blood glucose.(Throughout the intervention, approximately five hours.)
研究者
Anne-Sophie Worm Fenger
Principal investigator, MD, PhD fellow
Rigshospitalet, Denmark