A study to determine the effect of adjunct Vitamin D treatment in pulmonary tuberculosis patients with Vitamin D deficient.

Not Applicable

Completed

• Conditions: Health Condition 1: A150- Tuberculosis of lung

• Registration Number: CTRI/2021/11/037914
• Lead Sponsor: Dr Harish Chandra

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-11-05
• Last Update Posted: 6 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 130

Inclusion Criteria

Newly diagnosed stable Pulmonary Tuberculosis patients with Vitamin D deficiency.

Exclusion Criteria

With history and biochemical evidence :-

1. Patient with extra pulmonary tuberculosis and drug resistant tuberculosis like MDR-TB, XDR-TB etc.

2. Chronic pulmonary disease like COPD, bronchial asthma, bronchiectasis, pulmonary fibrosis, pulmonary silicosis, sarcoidosis and pulmonary lobectomy.

3. Chronic Liver disease, Aspartate transaminase or Alanine transaminase more than 120 IU per Litre or total serum bilirubin more than 40 micromol per Litre.

4. Chronic Kidney disease, Nephrolithiasis, serum creatinine more than 250 micromol per Litre.

5. Malignancy

6. HIV infection

7. Hyperparathyroidism

8. Thyrotoxicosis

9. Chronic cardiac disease like angina, congestive heart failure, myocardial infarction, arrhythmia etc.

10. Cytotoxic drugs or other immunosuppressant treatment in the month preceding enrollment.

11. Serum corrected calcium more than 2.65 mmol per Litre.

12. Pregnant or breastfeeding.

13. Diabetes Mellitus.

14. Use of drugs affecting Vitamin D metabolism - Anticonvulsants, Glucocorticoids, Calcium and Theophylline.

Study & Design

• Study Type: Interventional
• Study Design: Not specified