NCT04317014已完成不适用
Polymorphisms in Obesity-related Genes Are Associated With Risk of Early Puberty in Han Chinese Girls
Shenzhen Center for Disease Control and Prevention0 个研究点目标入组 628 人开始时间: 2016年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 628
- 主要终点
- genotypes of SNPs in the obesity-related genes
研究概览
简要总结
childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.
详细描述
the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 7 Years 至 10 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of central precocious puberty or early and fast puberty.
排除标准
- •The participants who were not the first visit to the hospital and had been treated before.
- •The participants who were with endocrine disorders.
结局指标
主要结局
genotypes of SNPs in the obesity-related genes
时间窗: 3 months
the obesity-related SNPs in the LRRN6C, MAF, CYP27A1 and ETV5 genes are selected and the genotypes of these SNPs are determined with a MassARRAY system.
次要结局
未报告次要终点
研究者
Di Li
post doctor
Shenzhen Center for Disease Control and Prevention
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