Genetic Analysis of Childhood Obesity

• Conditions: Obesity
• Interventions: Other: Identification of genetic causes of obesity

• Registration Number: NCT02326480
• Lead Sponsor: Lille Catholic University

Brief Summary

Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-12-15
• Study First Submitted QC: 2014-12-22
• Study First Posted: 2014-12-29
• Study Start: 2015-01
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-02
• Last Update Posted: 2020-03-03
• Primary Completion: 2020-12
• Study Completion: 2021-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Not provided

Exclusion Criteria

• Common obesity
• Impossibility for blood sampling
• Impossibility to receive information
• Participation refusal of one of the parents
• Refusal to sign the informed consent
• Neither Healthcare coverage nor insurance

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Isolated obesity	Identification of genetic causes of obesity	Identification of genetic causes of obesity
Familial obesity	Identification of genetic causes of obesity	Identification of genetic causes of obesity

Primary Outcome Measures

Name	Time	Method
To identify the number of mutations or genes involved in genetic causes of Child obesity	first day of enrollement	Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes

Secondary Outcome Measures

Name	Time	Method
To determine number of phenotypes associated to the child obesity genotype	first day of enrollement
To identify the number of new mutations present in the children's DNA and absent from their parents' genomes	first day of enrollement	This approach will allow the identification of specific mutations that are present only in affected children but not in their parents
To identify the number of mutations in the population	first day of enrollement

Trial Locations

Locations (1)

Hôpital Saint Vincent de Paul; 🇫🇷 Lille, France