Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 400
- 主要终点
- Number of patients with gene mutations or genetic variants in children with early-onset severe obesity
研究概览
简要总结
The aim of the present study is to identify new obesity-related genetic defects and determine their association with clinical manifestations in families with childhood-onset severe obesity. The investigators hypothesize that by exploring children with severe early-onset obesity they can find new obesity-related genetic defects and by exploring obesity-associated clinical manifestations the investigators can elucidate the outcomes of severe childhood obesity.
详细描述
Obesity is a complex disorder with many contributing genetic and environmental factors. The genetic causes and mechanisms for severe childhood obesity are still incompletely understood. It is acknowledged that obesity in some individuals could be a consequence of rare genetic variants with strong effect - these rare variants might be population specific.
The aims of this study are to determine
- inheritance patterns of early-onset obesity
- new obesity-related genetic variants and disease-causing gene mutations
- the association between obesity-related genetic defects and clinical manifestations
- the association between obesity-related genetic defects and psychiatric symptoms
in patients with early-onset obesity and their first-degree relatives
Significant advancements in genetic methodology provide new tools to explore genetic defects underlying obesity. Family-based approach provides several advantages compared to cohort studies to investigate genetic determinants of complex diseases.The unique genetic composition of the Finnish population enables identification of novel genetic entities.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 10 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children and adolescents age 10-18 years
- •height-adjusted weight >60 % before the age of 7 years.
- •Finnish descent
排除标准
- •patients with a known endocrine or genetic disorder underlying obesity (e.g. Prader-Willi syndrome, hypercortisolism, hypothyroidism)
结局指标
主要结局
Number of patients with gene mutations or genetic variants in children with early-onset severe obesity
时间窗: Baseline, first day of enrollment
次要结局
未报告次要终点
研究者
Petra Loid
MD
Helsinki University Central Hospital