MedPath

Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers

Completed
Conditions
Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations
Registration Number
NCT02849977
Lead Sponsor
Rhythm Pharmaceuticals, Inc.
Brief Summary

The purpose of this screening study is to identify people who have a rare genetic cause of obesity - specifically three genetic variants (a change in the DNA structure) of the POMC, PCSK1 and LepR genes that are currently known to result in obesity.

This screening study will not include any investigational drugs. You will be asked to provide a DNA sample and answer some questions about your medical history and hunger.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
5966
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Identification of individuals with POMC, LepR or PCSK1 genetic mutations1 Year
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (57)

Synexus Clinical Research US, Inc. - Simon Williamson Clinic, PC

🇺🇸

Birmingham, Alabama, United States

Synexus Clinical Research US, Inc. - Phoenix Southeast

🇺🇸

Chandler, Arizona, United States

Clinical Research Advantage Inc.

🇺🇸

Mesa, Arizona, United States

Tucson Neuroscience Research - M3 Wake Research

🇺🇸

Tucson, Arizona, United States

PRI, LLC - Los Alamitos - M3 Wake Research

🇺🇸

Los Alamitos, California, United States

Axis Clinical Trails

🇺🇸

Los Angeles, California, United States

Axis Clinical Trials

🇺🇸

Los Angeles, California, United States

PRI, LLC - Newport Beach - M3 Wake Research

🇺🇸

Newport Beach, California, United States

Nemours Foundation Alfred Dupont Children's Hospital

🇺🇸

Wilmington, Delaware, United States

Children's National Medical Center

🇺🇸

Washington, District of Columbia, United States

Scroll for more (47 remaining)
Synexus Clinical Research US, Inc. - Simon Williamson Clinic, PC
🇺🇸Birmingham, Alabama, United States

MedPath

Empowering clinical research with data-driven insights and AI-powered tools.

© 2025 MedPath, Inc. All rights reserved.