the Association Between Obesity and Early Puberty

Completed

• Conditions: Early Puberty

• Registration Number: NCT04317014
• Lead Sponsor: Shenzhen Center for Disease Control and Prevention

Brief Summary

childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.

Detailed Description

the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.

Study Timeline

• Study Start: 2016-09-01
• Primary Completion: 2018-05-20
• Study Completion: 2019-06-04
• Status Verified: 2020-03
• Study First Submitted: 2020-03-17
• Study First Submitted QC: 2020-03-18
• Last Update Submitted: 2020-03-18
• Study First Posted: 2020-03-20
• Last Update Posted: 2020-03-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 628

Inclusion Criteria

• Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria

• The participants who were not the first visit to the hospital and had been treated before.
• The participants who were with endocrine disorders.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
genotypes of SNPs in the obesity-related genes	3 months	the obesity-related SNPs in the LRRN6C, MAF, CYP27A1 and ETV5 genes are selected and the genotypes of these SNPs are determined with a MassARRAY system.