Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity
- Conditions
- Monogenic Obesity
- Interventions
- Biological: Salivary Sampling
- Registration Number
- NCT05362565
- Lead Sponsor
- University Hospital, Bordeaux
- Brief Summary
Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene ("monogenic obesity"). The diagnosis of these rare forms can lead to personalized management (new treatments, prognosis, adapted hygienic and dietary rules) and family screening. The use of a panel covering the known causes of monogenic obesity on a pediatric cohort of severe and early obesity will allow to evaluate the relevance of these analyses to adapt the management of this type of patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Recruitment age: 2-17 years
- Body mass index, greater than the International Obesity Task Force (IOTF) 30 curve before the age of 5
- Care at the specialized pediatric obesity center (CSO) of the Bordeaux University Hospital
- Informed consent signed
Exclusion Criteria
- no informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patient with salivary sampling Salivary Sampling -
- Primary Outcome Measures
Name Time Method Positivity rate of patients for whom a diagnosis of monogenic obesity will be obtained when all analyses have been performed. Inclusion visit
- Secondary Outcome Measures
Name Time Method Number of patients for whom a genetic finding will have changed management and description of changes. Inclusion visit Number of Patients eligible for a drug targeting single-gene obesity Inclusion visit
Trial Locations
- Locations (1)
Centre Hospitalier Universitaire de Bordeaux
🇫🇷Bordeaux, France