The relationship between cough reflex testing (CRT) and silent aspiration in acute exacerbation of chronic obstructive pulmonary disease (COPD)

Waitemata District Health Board0 sites50 target enrollmentNovember 20, 2013

Overview

No summary available.

Registry

who.int

Start Date

November 20, 2013

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•50 consecutive patients admitted to North Shore Hospital with acute exacerbation of chronic obstructive pulmonary disease (COPD) as primary diagnosis or reason for admission will be approached for participation in the study. Hospital admission lists will be screened daily to identify eligible patients.

•Deemed palliative as per medical team (identifying aspiration for these patients would unlikely change their medical management and reversibility of cough reflex is considered unlikely);
•Neurological or neuromuscular impairments or progressive neurological disease e.g. stroke, bulbar and pseudobulbar palsy, Parkinson’s Disease, Multiple Sclerosis, Dementia, Motor Neurone Disease (to avoid referral bias due to known associations with dysphagia);
•Endotracheal intubation within previous three months (based on Mokhlesi et al., 2002\);
•Previous or current tracheostomy;
•Cognitive impairment which would preclude obtaining informed consent;
•Current active smoking (smoking blunts cough reflex; Dicpinigaitis, 2003\);
•Reported clinical symptoms or diagnosis of gastro\-oesophageal reflux disease (GORD; can cause reduced Lx sensitivity; Phua et al., 2005\);
•Known or suspected swallowing impairment unrelated to COPD;
•Previous head and/or neck surgery, injury or radiation;
•Current use of angiotensin\-converting enzyme (ACE inhibitors; promotes cough \& increases tussive effect; Morice et al., 1987\);