ISRCTN96855098
Active, not recruiting
未知
A comparison and validation study of cough challenge responses evoked using two different bronchial provocation systems
niversity of Manchester0 sites24 target enrollmentSeptember 16, 2021
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Cough challenge responses
- Sponsor
- niversity of Manchester
- Enrollment
- 24
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Current inclusion criteria as of 21/06/2024:
- •1\. Aged \=18 years
- •2\. Normal spirometry (FEV1 and FVC %predicted of \=80%)
- •3\. No current or past history of chronic cough or any other respiratory disease
- •4\. No current or history of chronic pain, irritable bowel syndrome, psychiatric illness or chronic headaches
- •5\. No previous experience of performing cough challenges (capsaicin study arm only)
- •6\. Must cough at least 2 times on a single inhalation of any dose of capsaicin/citric acid during the visit 1 cough challenge
- •Previous inclusion criteria:
- •1\. Aged \=18 years
- •2\. Normal spirometry (FEV1 and FVC %predicted of \=80%)
Exclusion Criteria
- •Current exclusion criteria as of 21/06/2024:
- •1\. Current smoker or ex\-smoker with \>20 pack\-year history, and/or \<6 months abstinence
- •2\. Upper respiratory tract infection within the last 4 weeks
- •3\. Use of ACE inhibitors
- •4\. Use of anti\-depressants
- •5\. Use of centrally acting medications that may alter the cough reflex e.g. opiates
- •6\. History of drug or alcohol abuse
- •7\. Current pregnancy or breastfeeding
- •8\. Concomitant conditions that may alter cough reflex sensitivity e.g. diabetes mellitus, Parkinson’s disease, cerebrovascular disease
- •9\. Previous cough challenge experience (only applicable for capsaicin study arm)
Outcomes
Primary Outcomes
Not specified
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