The Impact of Medication Reviews Conducted in Primary Care on Hospital Admissions and Mortality - a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Region Skane
- 入组人数
- 369
- 主要终点
- hospital admission
研究概览
简要总结
The study is a follow-up of a randomized controlled study performed in 2011-2012 with medication reviews in elderly patients in Sweden. Additional data about mortality and hospital admissions have been collected.
详细描述
Background Drug-related problems among the elderly population are common and increasing. Multi-professional medication reviews (MR) have arisen as a method to optimize drug therapy for frail elderly patients. Research has not yet been able to show conclusive evidence of the effect of MRs on mortality or hospital admissions. Aim The aim of this study was to assess the impact of MRs' on hospital admissions and mortality after six and 12 months in a frail population of 369 patients in primary care in a randomized controlled study. Methods Patients were blindly randomized to an intervention group (receiving MRs) and a control group (receiving usual care). Descriptive data on mortality and hospital admissions at six and 12 months were collected. Survival analysis was performed for time to death and time to the first hospital admission within 12 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Investigator)
盲法说明
Closed envelopes
入排标准
- 年龄范围
- 75 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age>75 years, living in nursing homes or community-dwelling with municipality-provided care, with multi-dose drug dispensing
排除标准
- •lack of multi-dose drug dispensing, living at home with no municipality-provided care, <75 years old
研究组 & 干预措施
Intervention
Patients in the intervention groups received multi-professional medication reviews. A nurse performed a symptom evaluation, a pharmacist assessed the drug list and made adjustment suggestions and finally a physician took action and performed medication changes.
干预措施: Medication review (Other)
Control
Patients were treated according to the usual routine.
结局指标
主要结局
hospital admission
时间窗: twelve months
time to the first hospital admission
Survival analysis
时间窗: twelve months
time to death
hospital admission
时间窗: six months
time to the first hospital admission
Survival analysis
时间窗: six months
time to death
次要结局
- mortality(twelve months)
- number of hospital admissions(twelve months)
- number of hospital admissions(six months)
- mortality(six months)