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Prospective Observational Study of Adjuvant Hormone Treatment in Estrogen-receptor Positive Premenopausal Early Breast Cancer Patients

Active, not recruiting
Conditions
Early Breast Cancer
Registration Number
NCT05730647
Lead Sponsor
Consorzio Oncotech
Brief Summary

This will be a prospective, multicenter, observational study. The primary objective is to record the choice, in clinical practice, of adjuvant hormone therapy (tamoxifen, tamoxifen + LhRh, aromatase inhibitors + LhRh) in premenopausal patients with estrogen-receptor positive breast cancer.

The secondary objective is to correlate adjuvant hormone therapy choices with biological characteristics of the tumor (T size, lymph node status, grade, receptor level, Ki67, HER2 status) and patient characteristics (age, prior chemotherapy treatment).

Detailed Description

Not available

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
Female
Target Recruitment
600
Inclusion Criteria
    • Premenopausal patients candidate to start adjuvant hormone therapy after breast cancer surgery
    • Age >18 years
    • No previous hormonal treatment
    • Written informed consent
Exclusion Criteria

1- Patient's inability to provide written informed consent 2 - Stage IV disease

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
To record the choice, in clinical practice, of adjuvant hormone therapy.21 months

Patients will be divided in groups according to type of adjuvant hormone therapy received:

1. tamoxifen

2. tamoxifen + LhRh

3. aromatase inhibitor + LhRh Differences between groups will be evaluated with Chi-square test and Mann-Whitney test.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (40)

Centro di Riferimento Oncologico- IRCCS

🇮🇹

Aviano, Italy

A.O. Consorziale Policlinico di Bari

🇮🇹

Bari, Italy

IRCCS Istituto Oncologico di Bari

🇮🇹

Bari, Italy

Osp. Papa Giovanni XXIII

🇮🇹

Bergamo, Italy

Università degli Studi "G.d'Annunzio" Chieti-Pescara

🇮🇹

Chieti, Italy

Presidio Ospedaliero "Antonio Perrino" ASL Brindisi

🇮🇹

Brindisi, Italy

ASST Lariana - Ospedale S. Anna

🇮🇹

Como, Italy

Azienda Ospedaliera S. Croce e Carle

🇮🇹

Cuneo, Italy

I.R.C.C.S. A.O.U San Martino - IST

🇮🇹

Genova, Italy

Azienda Ospedaliera Universitaria Careggi

🇮🇹

Firenze, Italy

Ospedale F.Renzetti di Lanciano

🇮🇹

Lanciano, Italy

Ospedale S.M. Goretti

🇮🇹

Latina, Italy

Ospedale Civile di Guastalla

🇮🇹

Guastalla, Italy

P.O. Vito Fazzi

🇮🇹

Lecce, Italy

AUSL Toscana Nord Ovest- Osp. Versilia

🇮🇹

Lido Di Camaiore, Italy

Ospedale di Macerata

🇮🇹

Macerata, Italy

A.O.Papardo

🇮🇹

Messina, Italy

AOU Federico II

🇮🇹

Napoli, Italy

A.O. Ospedale Civile di Legnano

🇮🇹

Legnano, Italy

Azienda Ospedaliera Specialistica dei Colli - Ospedale Monaldi

🇮🇹

Napoli, Italy

A.O.U Policlinico di Modena

🇮🇹

Modena, Italy

Istituto Nazionale dei Tumori - Fondazione G. Pascale

🇮🇹

Napoli, Italy

A.O.R.N. "A. Cardarelli"

🇮🇹

Napoli, Italy

Istituto Oncologico Veneto IRCCS

🇮🇹

Padova, Italy

A. O. U. Pisana - Ospedale S. Chiara

🇮🇹

Pisa, Italy

A.O.R. San Carlo

🇮🇹

Potenza, Italy

AUSL della Romagna- P.O. di Ravenna, Lugo e Faenza

🇮🇹

Ravenna, Italy

Ospedale di Prato

🇮🇹

Prato, Italy

IRCCS Arcispedale S.Maria Nuova

🇮🇹

Reggio Emilia, Italy

Fondazione Policlinico Gemelli

🇮🇹

Roma, Italy

Istituto Nazionale Tumori Regina Elena

🇮🇹

Roma, Italy

Ospedale San Camillo Forlanini

🇮🇹

Roma, Italy

Policlinico Universitario Campus Biomedico

🇮🇹

Roma, Italy

Istituto Clinico Humanitas Irccs

🇮🇹

Rozzano, Italy

Ospedale San Vincenzo

🇮🇹

Taormina, Italy

IRCCS Casa Sollievo della Sofferenza

🇮🇹

San Giovanni Rotondo, Italy

Presidio Ospedaliero Martini - ASL TO1

🇮🇹

Torino, Italy

Ospedale Santa Chiara

🇮🇹

Trento, Italy

Ospedale San Pio da Pietrelcina

🇮🇹

Vasto, Italy

Azienda Ospedaliera Universitaria SM Misericordia

🇮🇹

Udine, Italy

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