Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Using Pulpotomy in Mature Mandibular First Molars

Not Applicable

Recruiting

• Conditions: Irreversible Pulpitis
• Interventions: Procedure: pulpotomy

• Registration Number: NCT06613932
• Lead Sponsor: Future University in Egypt

Brief Summary

Clinical and Radiographic Assessment of L-PRF, Nanohydroxyapatite material combined with L-PRF scaffold in Vital pulp Therapy. Treatments in Mandibular First Molars with Closed Apices, Randomized Controlled Trial.

Detailed Description

pulpotomy by using 3 materials. The first group(control group ) uses hydroxyapatite material as a pulpotomy agent, and the second group uses L-PRF as a pulpotomy agent. the third group uses combined material (L-PRF = Nano hydroxyapatite )as a pulpotomy agent .. then assesses the clinical and radiographic result of the 2 interventions group with control group

Study Timeline

• Study Start: 2023-10-30
• Study First Submitted: 2024-08-16
• Status Verified: 2024-09
• Study First Submitted QC: 2024-09-25
• Last Update Submitted: 2024-09-25
• Study First Posted: 2024-09-26
• Last Update Posted: 2024-09-26
• Primary Completion: 2024-10-30
• Study Completion: 2024-10-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
hydroxyapatite	pulpotomy	using hydroxyapatite as a pulpotomy agent and reviewing its clinical and radiographic performance compared to the other groups
L-PRF	pulpotomy	using L-PRF as a pulpotomy agent and assessing the clinical and radiographic result compared to other groups
L-PRF combined with Nano-hydroxyapatite	pulpotomy	using the combined material (nanohydroxyapatite mixed to L-PRF ) and assessing the clinical and radiographic result compared to other groups

Primary Outcome Measures

Name	Time	Method
post operative Pain assessment	6, 12, 24, 72hours and 7 days after treatment	Pain evaluations were conducted preoperatively with numerical rating scale ( a verbal or writing determination of a pain level on a scale from 0 to 10, in which 0 represents no pain and 10 represents excruciating pain .

Secondary Outcome Measures

Name	Time	Method
Dentine bridge formation	12 months post operative	evaluating the thickness of dentine bridge formed after the procedure by comparing immediate post operative CBCT with the one year follow up scans

Trial Locations

Locations (1)

future university in Egypt; 🇪🇬 Cairo, New Cairo, Egypt