Efficacy of PRF Application on Clinical Parameters and GCF Platelet-derived Growth Factor-BB and Periostin Levels

Not Applicable

Completed

• Conditions: Periodontitis
• Interventions: Other: Platelet rich fibrin

• Registration Number: NCT05178771
• Lead Sponsor: University of Baghdad

Brief Summary

Determine the efficacy of the non-invasive application of PRF on periodontal clinical parameters(pocket reduction) and the levels of PDGF-BB and Periostin in the gingival crevicular fluid.

Detailed Description

The adjunctive use of PRF with conventional ScRp may improve clinical healing, decrease tissue morbidities such as pain and discomfort, increase patient acceptance, reduce treatment time. Since PRF can be utilized as a safe, natural method to repair tissues at a low cost. Our aim is to evaluate the effectiveness of the non-invasive application of PRF as an adjunct to ScRp in patients with stage III grade B periodontitis through measurements of gingival crevicular fluid levels of PDGF-BB and Periostin before and after treatment and compare it with ScRp alone. A split-mouth procedure will be performed to reduce confounders as possible.

Study Timeline

• Study First Submitted: 2021-12-16
• Study First Submitted QC: 2021-12-16
• Study First Posted: 2022-01-05
• Study Start: 2022-03-01
• Primary Completion: 2022-08-05
• Status Verified: 2022-09
• Study Completion: 2022-09-25
• Last Update Submitted: 2022-09-28
• Last Update Posted: 2022-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Systemically healthy patients.
• Patients with periodontitis.

Exclusion Criteria

1. Medical history of systemic disease: diabetes, pregnancy, or lactation.
2. Previous periodontal treatment for the last 6 months
3. Grade II mobility
4. Smoker or alcoholic patient.
5. Teeth with untreated caries, endodontic lesions
6. Symptoms of recent acute illness e.g., COVID-19 will be excluded as well

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
test site	Platelet rich fibrin	The test site will receive ScRp in addition to PRF

Primary Outcome Measures

Name	Time	Method
clinical parameters	4 weeks and 3 months	measurements of pocket depth in millimeter at baseline and at the end of study

Secondary Outcome Measures

Name	Time	Method
PDGF-BB and periostin level in GCF	4 weeks and 3 months	Measurement of PDGF-BB and periostin level in GCF in baseline data and at the end of study

Trial Locations

Locations (1)

Babylon University; 🇮🇶 Hilla, Babel, Iraq