Influence of Human Platelet Derivatives on Dental Implant
- Conditions
- Platelet-Rich FibrinDental ImplantationBone Substitute
- Interventions
- Biological: PRF membrane
- Registration Number
- NCT06044246
- Lead Sponsor
- Al-Mustansiriyah University
- Brief Summary
The goal of this randomized controlled trial is to evaluate the benefit of PRF membrane on bone around dental implant in patients who need treatment with dental implant.
Aims of the study:
* To study the effect of PRF membrane (with or without bone substitute on increasing bone dimension around dental implant.
* To investigate the effects of compositions of PRF (platelets count, WBC count) on bone healing.
- Detailed Description
Materials and methods:
PRF will be obtained from a blood sample that is taken from the patient at the time of surgery in 10-mL tubes, the blood-containing tube is placed in a centrifuge at specially controlled rotations, temperature and time. The result is the separation of blood, basically from two by-products, including PRF. The PRF clot will be placed in specific box ( P.R.F -System; Surgident, CE ) to create a PRF membrane with specific thickness that will be placed on the bone around dental implant.
Evaluation of the results
* Alveolar bone width around dental implant will be measured.
* Histological examination of the tissue that excised during dental implant uncover surgery.
* Evaluate pain by visual analogue score (VAS).
* Estimate the count of WBC and platelets in whole blood will be obtained from a laboratory results.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 30
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description experimental group PRF membrane Placing dental implant with PRF membrane treatment alone or combined with bone substitute.
- Primary Outcome Measures
Name Time Method Osseointegration Immediately after surgery, after 12 weeks (during uncover implant surgery) Evaluation of the changes in the degree of osseointegration will be performed using Osstell devise. \[Osstell ISQ device. (Stampgatan, Gteborg, Sweden)\] The Unit of measurement: ISQ (Implant Stability Quotient), which is a scale from 1 to 100.
Bone width Baseline (pre-surgery), immediately after the surgery, after 4 weeks, 6 weeks, 8weeks, 10 weeks, and 12 weeks. Measure the dimensional changes using special caliper (vernier) measurement tool, to evaluate the changes of bone width around dental implant. the Unit of measurement: millimeter (mm) (Bone and mucosa)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kadhimiya Teaching HospitalKadhimiya Educational Hospital
🇮🇶Baghdad, Alkadhmiya City, Iraq