Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 6
- 主要终点
- Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.
研究概览
简要总结
The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.
The main questions it aims to answer are:
- The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.
- The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.
Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :
- A semi-structured interview to check the participants eligibility and gather demographic data.
- Neuropsychological tests and questionnaires will then be administered.
- A relative of the study participant will help complete questionnaires.
详细描述
Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies.
To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •General inclusion criteria:
- •60 years and older
- •French-speaking and volunteering for the study
- •Living at home with a relative
- •Alzheimer's disease inclusion criteria:
- •Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
- •MMSE greater than or equal to 20
- •Inclusion criteria Parkinson's disease :
- •Diagnosis of Idiopathic Parkinson's disease
- •MMSE greater than or equal to 20
排除标准
- •No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
- •Autistic disorders
- •History of stroke or head trauma
- •Unstable medical condition (cancer)
- •Subject unable to read and/or write
- •Hearing impairment without hearing aids
- •Refusal of consent after information
- •Persons unable to give consent, research carried out in emergency situations, etc.)
- •Non-affiliation with a social security scheme
- •Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
- •Person under legal protection (guardianship, curatorship, legal protection)
- •Person participating in another research project with an exclusion period still in progress
结局指标
主要结局
Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.
时间窗: Baseline
Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.
次要结局
- Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group(Baseline)
- Correlation between Item 22 of the MusEQ-24 hetero-reported version and Wisconsin Card Sorting Test (WCST) for each group(Baseline)
- Correlation between item 22 of the MusEQ-24 hetero-reported version with 16-item free recall/indexed recall test (RL/RI- 16) for each group(Baseline)
- Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group(Baseline)
- Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group(Baseline)
- The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension(Baseline)
- Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Musical Cognition between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Semantic Musical Memory between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Sensitivity to musical reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Self-assessed musical engagement between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Memory recall during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of emotional experience during music listening during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Hedonic function reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Affective blunting between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
- Comparison of Depression symptoms(Baseline)
- Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Wisconsin Card Sorting Test (WCST) for each group(Baseline)
- Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the 16-item free recall/indexed recall test (RL/RI- 16) for each group(Baseline)
- Correlation between Barcelona Reward Music Questionnaire (BMRQ) and Lille's Apathy Rating Scale (LARS) subscale for each group(Baseline)
- Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group(Baseline)
- Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Wisconsin Card Sorting Test (WCST) for each group(Baseline)
- Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the 16-item free recall/indexed recall test (RL/RI- 16) for each group.(Baseline)
- Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group(Baseline)