Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment

University Hospital, Montpellier3 sites in 1 country120 target enrollmentFebruary 4, 2025

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Not specified
Sponsor: University Hospital, Montpellier
Enrollment: 120
Locations: 3
Primary Endpoint: Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.
Status: Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.

The main questions it aims to answer are:

The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.
The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.

Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :

A semi-structured interview to check the participants eligibility and gather demographic data.
Neuropsychological tests and questionnaires will then be administered.
A relative of the study participant will help complete questionnaires.

Detailed Description

Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies. To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.

Registry

clinicaltrials.gov

Start Date

February 4, 2025

End Date

December 1, 2025

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University Hospital, Montpellier

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•General inclusion criteria:
•60 years and older
•French-speaking and volunteering for the study
•Living at home with a relative
•Alzheimer's disease inclusion criteria:
•Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
•MMSE greater than or equal to 20
•Inclusion criteria Parkinson's disease :
•Diagnosis of Idiopathic Parkinson's disease
•MMSE greater than or equal to 20

Exclusion Criteria

•No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
•Autistic disorders
•History of stroke or head trauma
•Unstable medical condition (cancer)
•Subject unable to read and/or write
•Hearing impairment without hearing aids
•Refusal of consent after information
•Persons unable to give consent, research carried out in emergency situations, etc.)
•Non-affiliation with a social security scheme
•Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)

Outcomes

Primary Outcomes

Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.

Time Frame: Baseline

Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.

Secondary Outcomes

Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group(Baseline)
Correlation between Item 22 of the MusEQ-24 hetero-reported version and Wisconsin Card Sorting Test (WCST) for each group(Baseline)
Correlation between item 22 of the MusEQ-24 hetero-reported version with 16-item free recall/indexed recall test (RL/RI- 16) for each group(Baseline)
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group(Baseline)
Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group(Baseline)
The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension(Baseline)
Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Musical Cognition between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Semantic Musical Memory between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Sensitivity to musical reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Self-assessed musical engagement between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Memory recall during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of emotional experience during music listening during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Hedonic function reward between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Affective blunting between Alzheimer's, Parkinson's and healthy elderly groups(Baseline)
Comparison of Depression symptoms(Baseline)
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Wisconsin Card Sorting Test (WCST) for each group(Baseline)
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the 16-item free recall/indexed recall test (RL/RI- 16) for each group(Baseline)
Correlation between Barcelona Reward Music Questionnaire (BMRQ) and Lille's Apathy Rating Scale (LARS) subscale for each group(Baseline)
Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group(Baseline)
Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Wisconsin Card Sorting Test (WCST) for each group(Baseline)
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the 16-item free recall/indexed recall test (RL/RI- 16) for each group.(Baseline)
Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group(Baseline)