Magnetic Resonance Imaging of the Effect of Music Listening on Brain Activity Under Anesthesia
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Blood Oxygen Level Dependent (BOLD) Response to Sensory Stimuli During Sedation
研究概览
简要总结
This study is to better understand the systems-level neuronal mechanisms by which general anesthetics produce loss of consciousness.The researchers believe that anesthetics suppress consciousness by disrupting the functioning of large-scale brain networks that support information integration in the brain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •American Society of Anesthesiologist physical status of 1 (ASA-1), Healthy, non-smoking, no or minimal alcohol use
- •Right-handed
- •Body mass index (BMI) of less than 30
- •English speakers
排除标准
- •Medical contraindication to Magnetic Resonance Imaging (MRI) scanning
- •Unable to undergo MRI scanning because of possible pregnancy
- •BMI over 30
- •Tattoos in the head or neck region
- •Unwilling to abstain from alcohol for 24 hours prior to dosing
研究组 & 干预措施
Functional Magnetic Resonance Imaging
While music is played Noninvasive functional magnetic resonance (fMRI) imaging will be performed at the University of Michigan Health System, University Hospital, Department of Radiology.
The fMRI is done under anesthesia using propofol. The researchers will manually control the infusion of propofol to achieve target effect-site concentrations of 1.2, 1.6, 2.0, and 2.4 μg/ml in a stepwise fashion.
干预措施: Functional Magnetic Resonance Imaging (fMRI) (Other)
结局指标
主要结局
Blood Oxygen Level Dependent (BOLD) Response to Sensory Stimuli During Sedation
时间窗: 60 minutes
Music evoked activity was quantified by measurements of the fMRI BOLD signal. Neural response to a natural auditory stimulus, music, was assessed during both conscious and anesthetized states. Measurements were taken at baseline (30 minutes) and during anesthesia (60 minutes).
次要结局
- Average Squeeze Pressure Over 60 Minutes(60 minutes)
研究者
Anthony G Hudetz
Professor of Anesthesiology
University of Michigan