Immunohistochemical Expression of Polyoma Enhancer Activator 3 in Odontogenic Cysts and Tumors: An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- Immunohistochemical expression of polyoma enhancer activator 3 will be higher in odontogenic tumors as compared to cysts.
研究概览
简要总结
Protein kinase (MAPK) pathway activation is a significant event in the pathogenesis of odontogenic lesions.2,6 It has been observed that PEA3 is a major downstream effector of MAPK signaling, which is often abnormally activated in tumors. A literature review shows that very few studies have been conducted on the PEA3 marker in odontogenic lesions, which can further provide valuable information for diagnostic, prognostic, and therapeutic strategies. Therefore,the present study will be carried out to assess the expression of PEA3 in odontogenic cysts like the odontogenic keratocyst/dentigerous cyst and tumors such as ameloblastoma.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Tissue blocks of odontogenic cysts that have been verified histopathologically 2 Tissue blocks of odontogenic tumors that have been verified histopathologically.
排除标准
- •Insufficient clinical data Tissues where controls exhibit unexpected results Tissues fixed in fixatives other than neutral buffered formalin.
结局指标
主要结局
Immunohistochemical expression of polyoma enhancer activator 3 will be higher in odontogenic tumors as compared to cysts.
Immunohistochemical expression of polyoma enhancer activator 3 will be higher in odontogenic tumors as compared to cysts.
时间窗: NA
次要结局
未报告次要终点
研究者
Disha Naresh
Institute of Dental Sciences