Brain Substrates for Cardiovascular Stress Physiology
- Conditions
- Stress Reaction
- Interventions
- Other: Low-level laser therapy (LLLT)
- Registration Number
- NCT05298956
- Lead Sponsor
- Baylor University
- Brief Summary
Transcranial infrared laser stimulation is a non-invasive neuromodulation technique. The study will examine the effect of transcranial infrared laser stimulation on cardiovascular and metabolic responses to stress.
- Detailed Description
Physiological responses to stress may be a potential pathway by which psychological stress relates to cardiovascular disease. Disproportionate (metabolically exaggerated) stressor-evoked cardiovascular reactions may accelerate atherosclerosis or influence risk of greater cardiovascular disease endpoints. The aim of this project is to use an experimental approach to examine if neuromodulation (transcranial infrared laser stimulation) alters stressor-evoked metabolic and cardiovascular responses.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
18-30 years old
History of a diagnosed chronic medical or neurological disorder Current pregnancy Current illness or infection (e.g., cold, flu) Any condition that would prohibit them from engaging in physical exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Transcranial infrared laser stimulation Low-level laser therapy (LLLT) Participants will receive transcranial infrared laser stimulation to the right forehead. Sham Low-level laser therapy (LLLT) Participants will receive sham laser to the right forehead.
- Primary Outcome Measures
Name Time Method Oxygen consumption in response to acute psychological stress Immediately following intervention (up to 60 minutes) This measurement takes into account oxygen consumption at baseline and during the stress task.
Additional heart rate in response to acute psychological stress Immediately following intervention (up to 60 minutes) This measurement takes into account additional heart rate at baseline and during stress.
Heart rate in response to acute psychological stress Immediately following intervention (up to 60 minutes) This measurement takes into account heart rate at baseline and during the stress task.
- Secondary Outcome Measures
Name Time Method Perceived stress Immediately following intervention (up to 60 minutes) Ratings of perceived stressfulness (1 = not at all stressful, 7 = very stressful) of the acute psychological stress task
Trial Locations
- Locations (1)
Annie T. Ginty
🇺🇸Waco, Texas, United States