Effect of Non-surgical Peridontal Treatment on Cardiovascular Risk Markers in Patients With Severe Chronic Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 主要终点
- Endothelial nitric oxide synthase (eNOS)
研究概览
简要总结
The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
详细描述
A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 54 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of severe chronic periodontitis
- •Clinical diagnosis of periodontal health
排除标准
- •Systemic diseases such as diabetes, cardiovascular disease
- •Periodontal treatment within the previous year
- •Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months
- •Pregnant or lactating
- •Consumed alcohol
结局指标
主要结局
Endothelial nitric oxide synthase (eNOS)
时间窗: At the 3rd months after non-surgical periodontal treatment
Serum Concentration (pg/mL)
Homocysteine (Hcy)
时间窗: At the 3rd months after non-surgical periodontal treatment
Serum Concentration (nmol/mL)
Monocyte chemoattractant protein-1 (MCP-1)
时间窗: At the 3rd months after non-surgical periodontal treatment
Serum Concentration (ng/mL)
Asymmetric dimethylarginine (ADMA)
时间窗: At the 3rd months after non-surgical periodontal treatment
Serum Concentration (pg/mL)
次要结局
- Clinical periodontal parameter(At the 3rd months after non-surgical periodontal treatment)
研究者
Meltem Karsiyaka Hendek
Assistant Professor
Kırıkkale University