Comparison of Water Sorption Capacity and the Composition of Bronchial Fluids of Healthy Persons and Patients With Chronic Obstructive Bronchitis (COPD)

Completed

• Conditions: Healthy; COPD

• Registration Number: NCT04703023
• Lead Sponsor: Georg Nilius, Prof DR med

Brief Summary

Pilot basic research study on the properties of bronchial mucus. Examination of the sorption and desorption properties, mucin concentration, and structure of the mucus from healthy airways compared to patients with Chronic Obstructive Pulmonary Disease (COPD).

Detailed Description

Mucus, of the correct composition, maintains airway hydration and protects the airway from inhaled particles through mucociliary transport. In chronic inflammatory airway diseases such as COPD or cystic fibrosis, infectious agents, inflammatory cells and products of inflammation such as DNA, increase mucus viscosity which results in decreased mucociliary clearance of inhaled particles, increasing the likelihood of respiratory infections. This pilot study is planned as basic research on the properties of bronchial mucus.

Water isotherms and efficient water activity (sorption and desorption) of the collected samples are examined in defined temperature and humidity settings using DVS Intrinsic (Dynamic Vapour Sorption System, Surface Measurement Systems, London, UK). Findings will provide insights into possible treatment programs targeted at altering specific mucus components.

Study Timeline

• Study Start: 2020-07-09
• Study First Submitted: 2021-01-07
• Study First Submitted QC: 2021-01-07
• Study First Posted: 2021-01-11
• Status Verified: 2023-05
• Primary Completion: 2023-05-02
• Study Completion: 2023-05-17
• Last Update Submitted: 2023-05-19
• Last Update Posted: 2023-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• Age>18
• COPD or other disease requiring bronchoscopy or elective surgery
• Signed informed consent form

Exclusion Criteria

• Not able to consent
• Linguistic, cognitive, or other obstacles

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sorption	5 days	Maximum water sorption per degree of saturation in percent of the dry mass weight of the mucus samples

Trial Locations

Locations (1)

Kliniken Essen-Mitte, Evang. Huyssens-Stiftung/Knappschaft gGmbH; 🇩🇪 Essen, NRW, Germany