Fetal Renal Artery Doppler in Patients With Preeclampsia

Recruiting

• Conditions: Preeclampsia
• Interventions: Other: fetal ultrasound

• Registration Number: NCT06395974
• Lead Sponsor: Assiut University

Brief Summary

Preeclampsia is a major devastating disorder affects 2:10% of pregnancies worldwide. preeclampsia may be associated with placental insufficiency which may cause fetal blood redistribution to essential organs like brain, heart, kidney.

Detailed Description

Preeclampsia is a major devastating medical condition that affects pregnant women after 20 weeks of pregnancy. It affects 2:10% of pregnancies worldwide according to World Health Organisation with higher incidence in developing countries.

Vascular endothelial dysfunction due to abnormal placentation is believed to be the main cause of multi-organ failure and uteroplacental insufficiency that occur in preeclampsia leading to major adverse effects in both mother and fetus.

Placental insufficiency causes a redistribution of fetal blood to essential organs ; brain, heart and adrenal glands by decreasing their vascular resistance on expense of peripheral organs such as kidney which exhibit increased vascular resistance and impaired perfusion. This is in contrast to normal pregnancies near term in which renal vascular resistance falls and increased blood flow to the kidneys is observed. Doppler ultrasound examination of vasculature of selected organs such as kidneys may have a role in detection of hemodynamic rearrangements that occur in cases of placental insufficiency and preeclampsia.

Study Timeline

• Study Start: 2023-11-01
• Study First Submitted: 2024-04-29
• Status Verified: 2024-05
• Study First Submitted QC: 2024-05-01
• Last Update Submitted: 2024-05-01
• Study First Posted: 2024-05-02
• Last Update Posted: 2024-05-02
• Primary Completion: 2024-11-01
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 88

Inclusion Criteria

• a) Preeclampsia:

  • Women with preeclampsia >28 weeks of pregnancy.

  • Singleton pregnancy.

  • Women with intrauterine growth restriction and abnormal amniotic fluid volume to simulate real world data.

    b) Control:

  • Women with healthy pregnancy matched by closest gestational age.

Exclusion Criteria

• ● Multiple pregnancy.

  • Known Congenital fetal malformations.
  • Women with other comorbidity such as ischemic heart disease, DM, Autoimmune disorders, kidney disease, neurological disorders, liver or haematological disorders.
  • Women unable to provide informed consent.
  • Women who refuse to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
preeclampsia	fetal ultrasound	-
control	fetal ultrasound	-

Primary Outcome Measures

Name	Time	Method
fetal renal artery doppler indices	1 year	the difference between the Fetal renal artery Doppler indices between preeclamptic patients and women with healthy pregnancy
Middle cerberal artery doppler indices , Umbilical artery doppler indices and placental volume	1 year

Secondary Outcome Measures

Name	Time	Method
neonatal outcome	1 year	the ability of Fetal renal artery Doppler in prediction of neonatal complications.

Trial Locations

Locations (1)

Assiut university hospital; 🇪🇬 Assiut, Egypt