A clinical trial of the comparison of the effect of drug Na/K citrate per os plus hydration with hydration alone on serum creatinine in high-risk patients after receiving contrast

Qom University of Medical Sciences and Health Services Vice chancellor0 个研究点目标入组 400 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•The inclusion criteria are the existence of at least one risk factor of contrast-induced nephropathy, namely: 1- Moderate systolic heart failure [ (EF) Ejection Fraction between 30-45%]2- Diabetes mellitus 3- Older than 75 year-old 4- Moderate renal insufficiency (serum creatinine level between 1/5-2 mg/dl) 5- Hypotension (systolic blood pressure less than 90 mm Hg 6- Anaemia 7- History of hypertension. Exclusion criteria; 1- pregnancy and lactation 2- History of allergic reaction to contrast media 3- Occurrence of cardiogenic shock and pulmonary edema during study 4-Urgent catheterization 5- Serum creatinine level higher than 2 mg/dl and previous history of dialysis 6- Receiving contrast medium 48 h before and after the intervention 7- Receiving diuretics, N-acetylcystein, sodium bicarbonate, theophylline, dopamine, mannitol, fenoldopam, metformin and NSAID’S during the study 8- Requiring to continue hydration therapy (e.g., sepsis condition) 9-Severe heart failure [left ventricular ejection fraction (LVEF) less than 30%]

发起方

Qom University of Medical Sciences and Health Services Vice chancellor