IRCT2016033118389N4
Completed
Phase 3
A clinical trial of the comparison of the effect of oral Nicorandil plus hydration with hydration alone on serum creatinine in high-risk patients after receiving contrast
Qom University of Medical Sciences and Health Services Vice chancellor0 sites128 target enrollmentTBD
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Acute renal failure.
- Sponsor
- Qom University of Medical Sciences and Health Services Vice chancellor
- Enrollment
- 128
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •The inclusion criteria were the existence of at least one risk factor of contrast\-induced nephropathy, including 1\) Moderate systolic heart failure \[30% \< (EF) Ejection fraction \< 45%] 2\) Diabetes 3\) Age\> 75 years 4\) Moderate renal insufficiency (1/5mg/ dL\< Cr \< 2mg/ dL 5\) Hypotension (systolic blood pressure \< 90 mm Hg 6\) Anemia 7\) History of hypertension Exclusion criteria: 1\- Pregnancy and lactation 2\- Allergy to radiographic contrast 3\- Have cardiogenic shock and pulmonary edema during study 4\- emergency catheterization 5\- Serum creatinine levels\> 2 mg/dL and preexisting dialysis 6\- Exposure to contrast medium 48 h pre\- and post\-coronary angiography 7\- Receive of diuretics, N\-acetylcystein, sodium bicarbonate, Theophylline, Dopamine, Fenoldopam and NSAID’S during the study 8\- Needs to continuous hydration therapy (e.g., sepsis) 9\-severe heart failure (EF\<\=30%)
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Not specified
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