A clinical trial of the comparison of the effect of oral Nicorandil plus hydration with hydration alone on serum creatinine in high-risk patients after receiving contrast

Qom University of Medical Sciences and Health Services Vice chancellor0 个研究点目标入组 128 人开始时间: 待定最近更新: 2018年2月22日

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•The inclusion criteria were the existence of at least one risk factor of contrast-induced nephropathy, including 1) Moderate systolic heart failure [30% < (EF) Ejection fraction < 45%] 2) Diabetes 3) Age> 75 years 4) Moderate renal insufficiency (1/5mg/ dL< Cr < 2mg/ dL 5) Hypotension (systolic blood pressure < 90 mm Hg 6) Anemia 7) History of hypertension Exclusion criteria: 1- Pregnancy and lactation 2- Allergy to radiographic contrast 3- Have cardiogenic shock and pulmonary edema during study 4- emergency catheterization 5- Serum creatinine levels> 2 mg/dL and preexisting dialysis 6- Exposure to contrast medium 48 h pre- and post-coronary angiography 7- Receive of diuretics, N-acetylcystein, sodium bicarbonate, Theophylline, Dopamine, Fenoldopam and NSAID’S during the study 8- Needs to continuous hydration therapy (e.g., sepsis) 9-severe heart failure (EF<=30%)

发起方

Qom University of Medical Sciences and Health Services Vice chancellor