ISRCTN87182483
Active, not recruiting
未知
Can the use of echocardiographic derived myocardial work predict outcomes in patients with severe aortic stenosis prior to transcatheter aortic valve intervention
ewcastle upon Tyne Hospitals NHS Foundation Trust0 sites140 target enrollmentDecember 12, 2022
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- ewcastle upon Tyne Hospitals NHS Foundation Trust
- Enrollment
- 140
- Status
- Active, not recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Severe aortic stenosis with a peak velocity (\>4\.0m/s), mean gradient (\>40mmHg) and an aortic valve area \<1\.0cm on transthoracic echocardiography requiring a transcatheter aortic valve intervention.
- •2\. Patients with low\-flow aortic stenosis (peak gradient \<4\.0m/s with AVA \<1\.0cm2\) who require a TAVI will also be invited to participate
Exclusion Criteria
- •1\. Age under 18 years old
- •2\. Mild or moderate aortic stenosis (\<4\.0m/s), mean gradient (\<40mmHg), and aortic valve area \>1\.0cm
- •3\. Suboptimal image quality which does not allow for quantitative left ventricular function assessment by Biplane Simpson, myocardial deformation imaging and myocardial work
- •4\. Poorly controlled arrhythmias or more than moderate mitral regurgitation
- •5\. Unable to tolerate a transthoracic echocardiogram
- •6\. Do not provide consent
Outcomes
Primary Outcomes
Not specified
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