Feasibility of High Intensity Interval Training in Survivors of Childhood, Adolescent, and Young Adult Hodgkin Lymphoma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Participation rate (percent of eligible participants approached who enroll)
研究概览
简要总结
This pilot study evaluates the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, and young adult Hodgkin lymphoma within 24 months of completing treatment. Preliminary efficacy of the HIIT intervention for improved cardiorespiratory fitness, body composition, physical function, autonomic response to exercise, peripheral neuropathy, biological aging markers, and physical activity will also be evaluated.
Primary Objective:
To determine the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, and young adult Hodgkin lymphoma within 24 months of completing treatment.
Feasibility will be assessed by:
- Participation Rate: Number of eligible survivors approached who enroll.
- Completion Rate: Number of scheduled HIIT sessions attended and number of enrolled participants who complete post-intervention testing.
详细描述
Hodgkin lymphoma survivors face elevated risks of cardiovascular disease and premature aging. HIIT, which alternates high-intensity effort with recovery periods, has shown benefits in adult cancer survivors but has not been tested in younger populations. This study will assess whether recently treated survivors can complete a remotely supervised 12-week HIIT program and evaluate its effects on multiple health outcomes. Participants will undergo baseline and post-intervention assessments including exercise testing, body composition, autonomic function, and blood biomarkers. The intervention is delivered via a secure web-based platform with live supervision by exercise physiologists.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participant has been diagnosed with Hodgkin lymphoma between the ages of 10 to 25 years.
- •Participant is between the ages of >10 and <25 years old the time of enrollment.
- •Participant has completed treatment (end of chemotherapy for those not receiving radiation therapy or end of radiation therapy) for Hodgkin lymphoma within 24 months prior to enrollment and recovered from any acute treatment-related adverse events.
- •Participant has been medically cleared to participate in physical activity.
- •Participant verbalizes understanding of directions for use of the web-based platform on the study provided iPad and heart rate monitor.
排除标准
- •Participant has evidence of relapsed disease.
- •Participant has a diagnosis of acute heart failure.
- •Participant reports currently participating in HIIT training or >420 minutes per week of moderate to vigorous physical activity.
- •Female participant who is currently pregnant.
研究组 & 干预措施
HIIT Intervention Group
Participants will complete a 12-week HIIT program with three 25-minute sessions per week. Each session includes warm-up, five cycles of high-intensity intervals (80-95% peak HR) and recovery periods (50-60% peak HR), and cool-down.
干预措施: High Intensity Interval Training (HIIT) (Behavioral)
结局指标
主要结局
Participation rate (percent of eligible participants approached who enroll)
时间窗: Trial completion (12 weeks)
Descriptive statistics will be reported
Completion rate (percentage of scheduled HIIT sessions attended and percentage of post-intervention testing sessions completed)
时间窗: Trial completion (12 weeks)
Descriptive statistics will be reported
次要结局
未报告次要终点