Comparison between effects of intravenous infusion Ibuprofen vs Morphine – Paracetamol on blood Platelet functio

Phase 3

• Conditions: supratentorial brain lesions.; Benign neoplasm of brain, supratentorial; D33.0

• Registration Number: IRCT20210506051200N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 June 2021

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

All surgeries for supratentorial lesions
No history of coagulation disorders
No history of gastrointestinal disease
No history of liver disease
Discontinue drugs that cause coagulation disorders
No history of heart disease
No history of renal failure (creatinine clearance <70 mL / min, oliguria or dialysis within 28 days before surgery)
No history of diabetes
No history of asthma
Absence of 2 or more of the following:Alanine aminotransferase> 165 U / L, aspartate transaminase>, 120 U / L Alkaline phosphatase> 345 U / L (three cases too normal)
Inability to obtain the consent of the patient or companions
No history of disorders due to hypersensitivity to ibuprofen, aspirin, nonsteroidal anti-inflammatory drugs, COX-2 inhibitors
- Women in non-pregnancy status
No long-term use of anticonvulsant drugs
No dependence or tolerance on drugs
Weight higher than 30 kg
No gastrointestinal bleeding during the last 6 weeks
Do not take warfarin, lithium or concomitant use of lasix and angiotensin converting enzyme inhibitors

Exclusion Criteria

Hematocrit less than 25% during surgery
Reduction of body temperature to less than 36 ° C

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Platelet function using PFa-100(CBC, PT, PTT, Ca2+, PFa-100, INR, Fibrinogen, serum osmolality, ABG). Timepoint: Once the Dora closure begins, a blood sample is taken first to measure coagulation abnormality using the PFa-100 test. Also, one hour after the injection is completed, blood samples are taken from both groups for the PFa-100 test. Method of measurement: The PFA-100 system is a platelet function analyzer designed to measure primary platelet-dependent homeostasis.(Platelet Function Assay or Platelet Function Analyzer): PFA-100.