Sickle Cell Improvement: Enhancing Care in the Emergency Department
- Conditions
- Sickle Cell Crisis
- Interventions
- Other: Care pathway
- Registration Number
- NCT05373771
- Lead Sponsor
- Medical College of Wisconsin
- Brief Summary
Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 36,000 children in the United States, approximately 90% of whom are Black. The disease is characterized by recurrent, severe pain crises which result in high rates of emergency department visits and hospitalizations, and decreased quality of life. The National Heart, Lung and Blood Institute, as well as the American Society of Hematology, have endorsed pain management guidelines regarding the timeliness of care for children presenting with these acute pain crises. These evidence-based guidelines are infrequently followed, resulting in increased pain and hospitalizations. In additional to other barriers to following the guideline, structural racism has been proposed as a significant contributor and the New England Journal of Medicine recently called for the institution of SCD-specific pain management protocols to combat structural racism and reduce time to opioid administration. The investigators' long-term goal is to improve the care and health outcomes of children with acute painful vaso-occlusive crisis treated in the emergency department. The overall aim of the investigators is to test a care pathway using multifaceted implementation strategies to increase guideline adherent care for children in the emergency department with acute painful vaso-occlusive crisis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 5328
- ED visit for uncomplicated pain crisis
- Sickle cell disease
- Receipt of at least one opioid
- Acute chest syndrome
- Fever > 38.5 in the ED
- priapism
- sickle cell trait
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Post-intervention Care pathway -
- Primary Outcome Measures
Name Time Method Timeliness of receipt of opioids A maximum of about 6 hours as all opioids received during the ED stay will be captured The percent of patients who receive first dose of opioids within 60 minutes of arrival and subsequent doses within 30 minutes of previous dose
- Secondary Outcome Measures
Name Time Method Median time to opioids A maximum of about 6 hours as all opioids received during the ED stay will be captured Median time from arrival to first opioid and then subsequent opioids
Percent of children hospitalized A maximum of about 6 hours as that is the typical maximum time to disposition for patients Disposition of hospitalization or discharge home
Trial Locations
- Locations (1)
Children's Wisconsin
🇺🇸Milwaukee, Wisconsin, United States