Down syndrome's estimated glomerular filtration rate trial

Not Applicable

Recruiting

• Conditions: Down syndrome

• Registration Number: JPRN-UMIN000047572
• Lead Sponsor: Teikyo University School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-05-01
• Last Update Posted: 17 October 2023
• Study Completion: 2024-03-31

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

Not provided

Exclusion Criteria

1) Abnormally low (less than 0.5) or abnormally high (greater than 0.5) ratio of urinary inulin excretion to blood inulin concentration 2) GFR greater than 150 ml/min/1.73m2 3) Patients who have had surgery for congenital heart disease or are expected to have surgery in the future 4) Patients with severe renal dysfunction (anuria, oliguria, on dialysis) 5) Respiratory failure or heart failure requiring oxygen administration 6) Patients undergoing treatment for gastrointestinal symptoms or common cold symptoms 7) Women who are pregnant, may become pregnant, or who are breast-feeding 8) Patients with neurological disorders taking antiepileptic drugs 9) Complications of chromosomal or genetic abnormalities other than DS 10) If the doctor in charge judges that the patient is inappropriate to participate in this trial

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relationship between glomerular filtration rate obtained from inulin clearance and the ratio of reference serum creatinine levels in Down syndrome to serum creatinine levels in affected children.

Secondary Outcome Measures

Name	Time	Method
Development of a polynomial approximation for the relationship between glomerular filtration rateobtained from inulin clearance and the commonly used estimated glomerular filtration rate equation.