Pruritus and Psoriasis - experimental analyses of itch in patients with psoriasis - PruriPsoExp

Klinik für Dermatologie, UKSH Campus Kiel0 sites60 target enrollmentOctober 28, 2020

Overview

No summary available.

Registry

who.int

Start Date

October 28, 2020

End Date

TBD

Last Updated

last year

Study Type

Observational

Sex

All

Sponsor

Klinik für Dermatologie, UKSH Campus Kiel

•Patients with psoriasis for at least 3 months with and without pruritus. Controlgroup (no skin diseases, no itch).
•\- Patients with pruritus should suffer from pruritus for at least 6 weeks
•\- patients with a stable anti\-psoriatic treatment for at least 4 weeks (with the exemption of UV\-therapy and systemic corticosteroids) and/or therapy\-naiv patients.
•\- no topical therapy for at least 3 weeks prior to testing in the location that will be evaluated
•\- One psoriatic lesion should be located on the back and/or thighs and/or buttocks.

•\- pregnancy or breastfeeding
•\- systemic corticosteroids or uv\-therapy within four weeks prior to testing
•\- intake of NSAR, analgetics, opioids or other medikations with an influence on itch within 7 days prior to testing.
•\- intake of antidepressents or medication against migraine within four weeks prior to testing
•\- intake of gabapentin within four weeks prior to testing
•\- application of emolients on the day of testing
•\- known intolerance of capsaicin, histamin, cowhadge or other relevant substances
•\- other skin lesions than psoriasis (e.g. infection, tattoos) in the testlocation
•\- patients with a known history of atopy
•\- patients with a known history of polyneurophaty or other neurological diseases