Pruritus and Psoriasis - experimental analyses of itch in patients with psoriasis - PruriPsoExp

Klinik für Dermatologie, UKSH Campus Kiel0 个研究点目标入组 60 人开始时间: 2020年10月28日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Patients with psoriasis for at least 3 months with and without pruritus. Controlgroup (no skin diseases, no itch).
•- Patients with pruritus should suffer from pruritus for at least 6 weeks
•- patients with a stable anti-psoriatic treatment for at least 4 weeks (with the exemption of UV-therapy and systemic corticosteroids) and/or therapy-naiv patients.
•- no topical therapy for at least 3 weeks prior to testing in the location that will be evaluated
•- One psoriatic lesion should be located on the back and/or thighs and/or buttocks.

•- pregnancy or breastfeeding
•- systemic corticosteroids or uv-therapy within four weeks prior to testing
•- intake of NSAR, analgetics, opioids or other medikations with an influence on itch within 7 days prior to testing.
•- intake of antidepressents or medication against migraine within four weeks prior to testing
•- intake of gabapentin within four weeks prior to testing
•- application of emolients on the day of testing
•- known intolerance of capsaicin, histamin, cowhadge or other relevant substances
•- other skin lesions than psoriasis (e.g. infection, tattoos) in the testlocation
•- patients with a known history of atopy
•- patients with a known history of polyneurophaty or other neurological diseases
•- patients with a history of diabetes
•- patients with a history of backpain
•- diseases that in the discretion of the investigators do not allow testing (e.g. psychosomatic or psychological diseases).
•- skin type IV-VI (Fitzpatrik)
•- patients/controlgroup unable to consent
•- drug or alcohol abuse

发起方

Klinik für Dermatologie, UKSH Campus Kiel